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Published on: September 24, 2020
Hispanic ethnicity and mortality among critically ill patients with COVID-19
Ana C Ricardo1, Jinsong Chen1, Stephanie M Toth-Manikowski1
1Department of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.
Insights
Hispanic patients with critical COVID-19 had higher mortality rates than non-Hispanic White patients. This disparity persisted despite Hispanic patients being younger and having fewer comorbidities, indicating a need for earlier care access.
Area of Science:
- Critical care medicine
- Public health
- Epidemiology
Background:
- Hispanic individuals in the U.S. face higher COVID-19 infection and mortality risks.
- Ethnic disparities in mortality among critically ill COVID-19 patients remain understudied.
Purpose of the Study:
- To investigate ethnic disparities in mortality among critically ill adults with COVID-19.
- To compare outcomes between Hispanic and non-Hispanic White critically ill COVID-19 patients.
Main Methods:
- A multicenter cohort study of 2153 critically ill COVID-19 patients across 67 U.S. hospitals.
- Analysis of 28-day mortality using multilevel logistic regression, adjusting for demographic and clinical factors.
Main Results:
- Hispanic patients (46.2%) were younger and had fewer comorbidities than non-Hispanic White patients.
- Hispanic patients experienced longer symptom duration before ICU admission.
- Adjusted analyses revealed a 44% higher odds of death for Hispanic patients (OR, 1.44; 95% CI, 1.12-1.84).
Conclusions:
- Critically ill Hispanic COVID-19 patients exhibit higher mortality than non-Hispanic White patients, irrespective of age and comorbidity burden.
- Earlier access to care for Hispanic individuals with COVID-19 is crucial.
- Addressing post-hospital discharge care disparities is essential.
Background:
Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this disparity exists among critically ill patients with COVID-19 is unknown.
Objective:
To evaluate ethnic disparities in mortality among critically ill adults with COVID-19 enrolled in the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID).
Methods:
Multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICU) at 67 U.S. hospitals from March 4 to May 9, 2020. Multilevel logistic regression was used to evaluate 28-day mortality across racial/ethnic groups.
Results:
A total of 2153 patients were included (994 [46.2%] Hispanic and 1159 [53.8%] non-Hispanic White). The median (IQR) age was 62 (51-71) years (non-Hispanic White, 66 [57-74] years; Hispanic, 56 [46-67] years), and 1462 (67.9%) were men. Compared with non-Hispanic White patients, Hispanic patients were younger; were less likely to have hypertension, chronic obstructive pulmonary disease, coronary artery disease, or heart failure; and had longer duration of symptoms prior to ICU admission. During median (IQR) follow-up of 14 (7-24) days, 785 patients (36.5%) died. In analyses adjusted for age, sex, clinical characteristics, and hospital size, Hispanic patients had higher odds of death compared with non-Hispanic White patients (OR, 1.44; 95% CI, 1.12-1.84).
Conclusions:
Among critically ill adults with COVID-19, Hispanic patients were more likely to die than non-Hispanic White patients, even though they were younger and had lower comorbidity burden. This finding highlights the need to provide earlier access to care to Hispanic individuals with COVID-19, especially given our finding of longer duration of symptoms prior to ICU admission among Hispanic patients. In addition, there is a critical need to address ongoing disparities in post hospital discharge care for patients with COVID-19.
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