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The International Standard for sisomicin
Journal of Biological Standardization
|October 1, 1986
Summary
An International Standard for the antibiotic Sisomicin was established through a global collaborative study. Each ampoule of this standard contains 35,200 International Units of Sisomicin activity.
Area of Science:
- Microbiology
- Pharmacology
- Analytical Chemistry
Background:
- Sisomicin is an aminoglycoside antibiotic used to treat bacterial infections.
- Standardization of antibiotic potency is crucial for accurate therapeutic dosing and regulatory compliance.
Purpose of the Study:
- To establish an International Standard for Sisomicin.
- To define the unit of activity for Sisomicin.
Main Methods:
- A collaborative assay involving seven international laboratories.
- Determination of Sisomicin activity through standardized testing protocols.
Main Results:
- An International Standard for Sisomicin was successfully established.
- The activity of each ampoule of the International Standard of Sisomicin was defined as 35,200 International Units (IU).
Conclusions:
- The established International Standard provides a reliable reference for Sisomicin quantification.
- This standardization facilitates consistent quality control and therapeutic use of Sisomicin worldwide.