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Updated: Sep 22, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Nationwide Industry-Led Community Exercise Program for Men With Locally Advanced, Relapsed, or Metastatic Prostate
Oliver Schumacher1,2, Daniel A Galvão1,2, Dennis R Taaffe1,2
1Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia.
JCO Oncology Practice
|May 18, 2022
Summary
A community exercise program effectively improved cardiovascular health and physical function in prostate cancer patients undergoing androgen-deprivation therapy. The program demonstrated feasibility and positive outcomes, particularly for those with poorer initial health measures.
Area of Science:
- Oncology
- Exercise Physiology
- Cardiovascular Health
Background:
- Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is linked to significant side effects, including obesity and cardiovascular disease.
- Managing these comorbidities is crucial for improving patient quality of life and treatment adherence.
Purpose of the Study:
- To evaluate the effectiveness of a community-based exercise program integrated with ADT.
- To assess the program's impact on body weight, cardiovascular health markers, and physical function in PCa patients.
Main Methods:
- 760 PCa patients receiving ADT were enrolled in a supervised group exercise program (aerobic and resistance training) over 10-18 weeks.
- Participants completed 16 moderate-to-vigorous intensity exercise sessions.
- Data on body weight, blood pressure, cardiorespiratory fitness, and muscle strength were collected.
Main Results:
- A significant reduction in waist circumference (-0.9 cm) and notable decreases in systolic (-3.7 mmHg) and diastolic (-1.7 mmHg) blood pressure were observed.
- Cardiorespiratory fitness and muscle strength showed significant improvements (P < .001).
- Participants with initially poorer health measures experienced the greatest benefits.
Conclusions:
- The community exercise program is feasible and effective for PCa patients on ADT.
- The program helps prevent weight gain, lowers blood pressure, and enhances physical function.
- This intervention offers a valuable strategy for managing ADT-related side effects.
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