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A novel predictor in patients with coronary chronic total occlusion: systemic immune-inflammation index: a

Muhammed Demir1, Mehmet Özbek1

  • 1Dicle University, School of Medicine, Department of Cardiology - Diyarbakır, Turkey.

Revista Da Associacao Medica Brasileira (1992)
|May 18, 2022
PubMed

Insights

The systemic immune-inflammation index predicts mortality in chronic coronary total occlusion patients but not other adverse cardiovascular events. Higher index scores correlate with lower survival and myocardial infarction-free survival rates.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Prognostic Biomarkers

Background:

  • Severe inflammation is linked to cardiovascular events, particularly in coronary artery disease patients.
  • The prognostic significance of the systemic immune-inflammation index (SII) in chronic coronary total occlusion (CTO) requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of the systemic immune-inflammation index (SII) in predicting mortality and clinical outcomes.
  • To determine the association between SII and major adverse cardiovascular events in patients with CTO.

Main Methods:

  • A cohort of 366 consecutive patients with CTO was analyzed.
  • Clinical endpoints included all-cause mortality, target vessel revascularization, myocardial infarction, and cerebrovascular events over a median follow-up of 49 months.
  • Statistical analyses comprised multivariate logistic and Cox regression, and Kaplan-Meier survival analysis.

Main Results:

  • The systemic immune-inflammation index (SII) was significantly associated with all-cause mortality (multivariate Cox regression).
  • Higher SII scores were linked to reduced survival rates and myocardial infarction-free survival.
  • SII did not show a significant association with target vessel revascularization, myocardial infarction, or cerebrovascular events.

Conclusions:

  • The systemic immune-inflammation index (SII) is a valuable tool for predicting mortality in patients with chronic coronary total occlusion.
  • SII demonstrated limited utility in predicting other adverse cardiovascular outcomes such as myocardial infarction or stroke.
  • Larger multicenter studies are recommended to further elucidate the role of SII in clinical outcomes for CTO patients.
Abstract

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