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Updated: Sep 22, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
A topology perspective on macrophages in melanoma metastasis
Alberto Mantovani1, Federica Marchesi2
1Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy; Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Abstract:
In this issue of Cell Reports Medicine, Martinek et al.1 provide a window into the regional specialization of macrophages infiltrating metastatic melanoma. Combining histo-cytometry and transcriptomics, they identify a signature of stromal macrophages with dendritic cell features and clinical relevance.
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