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Updated: Sep 22, 2025

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Atrial fibrillation in hypertrophic cardiomyopathy - A contemporary mini-review

Stylianos Dragasis1, Konstantinos Vlachos1, Ourania Kariki1

  • 1Onassis Cardiac Surgery Canter, Leof. Andrea Siggrou 356, Kallithea 176 74, Athens, Greece.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|May 18, 2022
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a common genetic heart condition. Atrial fibrillation (AF) in HCM patients worsens heart failure and increases stroke risk, necessitating focused management strategies.

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most frequent inherited cardiovascular disease.
  • HCM is a primary cause of heart failure and sudden cardiac death.
  • Atrial fibrillation (AF) is the most common arrhythmia in HCM patients, linked to left atrial enlargement.

Purpose of the Study:

  • To review current understanding of AF pathophysiology in HCM.
  • To identify risk factors for AF development in HCM.
  • To summarize contemporary management strategies for AF in HCM patients.

Main Methods:

  • Literature review of contemporary data.
  • Synthesis of information on AF pathophysiology, risk factors, and treatment.
  • Focus on patients with both HCM and AF.

Main Results:

  • AF presence in HCM accelerates functional decline.
  • AF increases heart failure hospitalizations.
  • AF elevates thromboembolic risk in HCM patients.

Conclusions:

  • AF significantly impacts prognosis in HCM.
  • Understanding AF pathophysiology is crucial for risk stratification.
  • Tailored management of AF is essential for improving outcomes in HCM.

Keywords:
Arterial thromboembolismAtrial fibrillationHypertrophic cardiomyopathy

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