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Clinical trial transparency in gastrointestinal endoscopy research
Shashank Garg1, Anam Rizvi2, Diana Wee2
1Arkansas Gastroenterology, North Little Rock, Arkansas, United States.
Endoscopy
|May 18, 2022
Summary
Clinical trial transparency is crucial. Endoscopic trials show high transparency, but nearly one-fifth of results remain unreported, highlighting a need for improved reporting on ClinicalTrials.gov.
Area of Science:
- Medical research
- Clinical trial management
- Gastroenterology
Background:
- Under-reporting clinical trial results hinders knowledge dissemination and meta-analysis accuracy.
- Clinical trial transparency, via publication or ClinicalTrials.gov, is essential for acknowledging patient contributions and understanding device efficacy.
- This study investigates transparency in endoscopic clinical trials.
Purpose of the Study:
- To assess the rate of clinical trial transparency in endoscopy.
- To evaluate the adherence to reporting results on ClinicalTrials.gov or in publications for endoscopic trials.
Main Methods:
- A systematic search of the ClinicalTrials.gov database was conducted for endoscopy trials up to October 2019.
- The reporting of results, either on ClinicalTrials.gov or in manuscript form, was recorded for each identified trial.
- Analysis included 923 trials: 801 completed and 122 terminated or suspended.
Main Results:
- Results were available for 81.4% (751/923) of the analyzed endoscopic trials.
- Publication rates for endoscopic trials (78.0%) were higher than those reported in other medical fields (40%-63%).
- Results were posted on ClinicalTrials.gov for only 18.2% (168/923) of trials, with 81.8% failing to report results on this platform.
Conclusions:
- Endoscopic clinical trials demonstrate a high level of transparency compared to other medical disciplines.
- Despite high publication rates, a significant portion of trials (nearly one-fifth) do not report their results.
- There is substantial room for improvement in reporting endoscopic trial outcomes on ClinicalTrials.gov.
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