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Updated: Sep 22, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Acute leukaemia: no reason to panic.
Eleni E Ladikou1, Iona Ashworth2, Dale Seviar3
1University Hospitals Sussex NHS Foundation Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK eleni.ladikou@nhs.net.
Acute leukaemia, including acute myeloid leukaemia (AML) and acute lymphoid leukaemia (ALL), involves rapid growth of immature white blood cells. Prompt diagnosis and treatment are crucial for survival.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Background:
- Acute leukaemia is a serious condition characterized by the rapid proliferation of immature leukocytes.
- It can be either myeloid or lymphoid in origin, leading to acute myeloid leukaemia (AML) or acute lymphoid leukaemia (ALL).
- Without timely intervention, acute leukaemia is rapidly fatal.
Purpose of the Study:
- To emphasize the critical need for prompt diagnosis and management of acute leukaemia.
- To highlight the life-threatening nature of untreated acute leukaemia.
- To underscore the importance of a multidisciplinary approach in managing these hematologic malignancies.
Main Methods:
- Review of the pathophysiology of acute leukaemia.
- Emphasis on the urgency of haematological consultation.
- Highlighting the necessity of prompt diagnostic investigations.
- Advocating for a multidisciplinary care model.
Main Results:
- Acute leukaemia necessitates immediate medical attention upon suspicion.
- Diagnostic confirmation and initiation of treatment must be expedited.
- Effective management relies on coordinated efforts from various medical specialists.
Conclusions:
- Early recognition and intervention are paramount in improving outcomes for patients with acute leukaemia.
- A comprehensive, multidisciplinary strategy is essential for optimal patient care and management of AML and ALL.
- Urgent haematological assessment is the critical first step in managing suspected acute leukaemia.
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