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Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
L Nava-Gómez1,2, I Calero-Vargas1,3, F Higinio-Rodríguez1,3
1Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México, Querétaro 76230, México.
Eneuro
|May 18, 2022
Summary
D-serine supplementation reversed age-related cognitive decline and brain changes in rats. This suggests D-serine may be a therapeutic target for age-related brain alterations.
Area of Science:
- Neuroscience
- Aging Research
- Pharmacology
Background:
- Brain aging naturally causes cognitive decline, linked to reduced N-methyl-D-aspartate receptor (NMDAR) function due to lower D-serine levels.
- The potential of D-serine supplementation to counteract these age-related brain changes remains unclear.
Purpose of the Study:
- To investigate the effects of D-serine supplementation on aging-associated alterations in cellular and large-scale brain systems in rats.
- To assess D-serine's impact on cognitive flexibility and neuronal morphology in aging.
Main Methods:
- Administered D-serine to aging rats.
- Assessed cognitive flexibility using behavioral tests.
- Analyzed frontal dendritic spine density and large-scale functional brain connectivity.
- Evaluated for nephrotoxicity and effects on kidney structure.
Main Results:
- D-serine supplementation reversed age-related decline in cognitive flexibility.
- Restored frontal dendritic spine density and partially improved large-scale functional connectivity.
- Did not induce nephrotoxicity; instead, it restored age-affected kidney epithelial cell thickness.
Conclusions:
- D-serine supplementation effectively reverses age-associated cognitive decline and brain alterations in rats.
- Restoring brain D-serine levels presents a potential therapeutic strategy for mitigating aging effects on the brain.
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