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A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
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Unexplained post-acute infection syndromes.

Jan Choutka1, Viraj Jansari2, Mady Hornig3

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Post-acute infection syndromes (PAISs) cause chronic disability after infections like COVID-19. Research is needed to understand the common mechanisms behind these debilitating conditions.

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Area of Science:

  • Infectious Diseases
  • Neurology
  • Immunology

Background:

  • Certain acute infections are known to cause unexplained chronic disability in a subset of patients.
  • Post-acute infection syndromes (PAISs) present a significant healthcare burden.
  • The mechanisms underlying PAISs remain poorly understood, representing a knowledge gap in medicine.

Purpose of the Study:

  • To review current knowledge on unexplained PAISs.
  • To provide context for post-acute sequelae of SARS-CoV-2 infection (PASC).
  • To highlight the necessity of basic research into the common etiopathogenesis of PAISs.

Main Methods:

  • Literature review of existing studies on PAISs.
  • Comparative analysis of symptom profiles across different PAISs.
  • Examination of clinical feature overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Main Results:

  • PAISs share similar symptom profiles regardless of the causative infectious agent.
  • Clinical features of PAISs overlap significantly with ME/CFS.
  • A common underlying etiopathogenesis is suggested for various PAISs.

Conclusions:

  • PAISs, including PASC, are not unique to SARS-CoV-2.
  • Understanding the common mechanisms of PAISs is crucial for effective treatment and management.
  • Further basic biomedical research is essential to elucidate the enigmatic chronic illnesses associated with PAISs.