Related Experiment Video

Updated: Sep 22, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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SIRT7 in the aging process

Francisco Alejandro Lagunas-Rangel1

  • 1Department of Surgical Sciences, Uppsala University, BMC, Husargatan 3, Box 593, 751 24, Uppsala, Sweden. francisco.lagunas@neuro.uu.se.

Cellular and Molecular Life Sciences : CMLS
|May 18, 2022
PubMed

Insights

This review explores the role of Sirtuin 7 (SIRT7) in aging. It examines SIRT7

Area of Science:

  • Molecular Biology
  • Gerontology
  • Biochemistry

Background:

  • Aging results from accumulated molecular and cellular damage.
  • Hallmarks of aging include genomic instability, loss of proteostasis, and cellular senescence.
  • Sirtuins are key enzymes in aging and longevity; SIRT7 is the least studied human sirtuin.

Purpose of the Study:

  • To analyze the association between SIRT7 and the hallmarks of aging.
  • To investigate SIRT7's role in age-associated diseases like cardiovascular diseases, obesity, osteoporosis, and cancer.

Main Methods:

  • Literature review and analysis of existing studies on SIRT7.
  • Correlation of SIRT7 functions with aging hallmarks and diseases.

Main Results:

  • SIRT7 plays roles in ribosomal RNA expression, DNA repair, and chromatin compaction.
  • Evidence suggests a link between SIRT7 and age-related processes.
  • SIRT7 is implicated in cardiovascular diseases, obesity, osteoporosis, and cancer.

Conclusions:

  • SIRT7 is significantly associated with multiple hallmarks of aging.
  • Further research into SIRT7's functions may reveal therapeutic targets for age-related diseases.
Keywords:
Aging-associated diseasesHallmarks of agingNucleolusRibosomal RNASirtuins

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