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Valve-Sparing Aortic Root Replacement in a Patient With an FLNA Variant

Adam J Lobbestael1, Caleb P Bupp1,2, Marcus P Haw1,3

  • 112268Michigan State University College of Human Medicine, Grand Rapids, MI, USA.

World Journal for Pediatric & Congenital Heart Surgery
|May 19, 2022
PubMed
Summary

A patient with an FLNA variant experienced aortic root dilation. Valve-sparing aortic root replacement using the David procedure, with modifications for tissue fragility, was successful. Genetic information guided surgical planning.

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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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