Related Experiment Video

Updated: Sep 22, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

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A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Oncology
|May 19, 2022
PubMed

Insights

MicroRNA-15b-5p (miR-15b-5p) plays a dual role in cancer, acting as both an oncogene and tumor suppressor. Its dysregulation is linked to poor outcomes in various cancers and contributes to several non-malignant diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA-15b-5p (miR-15b-5p), encoded by the MIR15B gene on chromosome 3q25.33, is implicated in numerous diseases.
  • Its involvement spans both malignant conditions (cancers) and non-malignant diseases, including cardiovascular and neurodegenerative disorders.

Purpose of the Study:

  • To review the multifaceted roles of miR-15b-5p in both cancer and non-cancerous conditions.
  • To consolidate current understanding of miR-15b-5p's involvement in disease pathogenesis.

Main Methods:

  • Literature review of studies investigating miR-15b-5p.
  • Analysis of its expression and functional impact in various pathological contexts.

Main Results:

  • miR-15b-5p exhibits context-dependent functions in cancer, acting as both an oncogene and a tumor suppressor.
  • Dysregulation of miR-15b-5p in patient samples correlates with adverse outcomes in multiple cancer types.
  • miR-15b-5p is involved in the pathogenesis of diverse non-malignant conditions, including cardiovascular diseases and neurodegenerative disorders.

Conclusions:

  • miR-15b-5p is a significant regulator in both oncogenesis and non-malignant disease progression.
  • Understanding miR-15b-5p's complex roles is crucial for developing targeted therapeutic strategies.
Keywords:
biomarkercancerexpressionmalignancemiR-15b-5p

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