Related Experiment Video
Updated: Sep 22, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Clinicoradiological Features in Progressive Supranuclear Palsy Comorbid with Argyrophilic Grains
Keita Sakurai1, Daita Kaneda2, Satoru Morimoto3
1Department of Radiology National Center for Geriatrics and Gerontology Obu Japan.
Background:
Contrary to pure cases, the influence of comorbid argyrophilic grain disease (AGD) in progressive supranuclear palsy (PSP) has not been sufficiently evaluated.
Objectives:
We compared the clinicoradiological features of 12 patients with PSP with (PSPw/AG) and 8 patients without AGD (PSPw/oAG).
Methods:
Medical records and magnetic resonance imaging were checked retrospectively from a single brain bank database.
Results:
Other than AGD, no differences were observed in any other neurodegenerative pathologies between the 2 groups. Ages at onset and deaths of patients with PSPw/AG were higher than those of patients with PSPw/oAG (77.9 ± 4.9 vs. 68.9 ± 5.9, and 87.0 ± 5.7 vs. 78.1 ± 5.0; P = 0.003 and P = 0.002, respectively). In addition to the later onset of motor symptoms, initial amnestic presentations were limited to 5 patients with PSPw/AG. Both characteristic midbrain atrophy and severe ambient gyrus atrophy were detected exclusively in 8 patients with PSPw/AG.
Conclusions:
Initial amnestic presentations and ambient gyrus atrophy may be characteristic of PSPw/AG.
Related Concept Videos
Parkinson's Disease: Overview
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Neural Regulation
Glaucoma: Overview
Photoreceptors and Visual Pathways

