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Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of PLOD2
Qiqi Xu1, Na Kong1, Yiguo Zhao1
1General Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Frontiers in Genetics
|May 19, 2022
Summary
The PLOD2 gene is highly expressed in most cancers and linked to poorer patient survival. This suggests PLOD2 could be a valuable biomarker for cancer diagnosis and prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Previous research indicates a role for PLOD2 in tumorigenesis.
- The broad significance of PLOD2 across various cancers requires further elucidation.
Purpose of the Study:
- To comprehensively analyze the role of PLOD2 in tumorigenesis across diverse cancer types.
- To evaluate PLOD2 as a potential diagnostic and prognostic biomarker in cancer.
Main Methods:
- Integrated analysis of GTEx, The Cancer Genome Atlas (TCGA), and Cancer Cell Line Encyclopedia (CCLE) databases for PLOD2 expression.
- Prognostic analysis correlating PLOD2 expression with patient survival in various cancers, including gastric cancer.
- Investigation of PLOD2's association with tumor immune infiltration, immune checkpoints, microenvironment scores, and immunotherapy biomarkers.
- Immunohistochemistry validation of PLOD2 overexpression in gastric cancer tissues.
Main Results:
- PLOD2 exhibits differential expression in normal tissues and is significantly upregulated in most tumors.
- Reduced PLOD2 expression correlates with improved overall survival in several cancers, notably gastric cancer (HR 0.616, p = 0.004).
- PLOD2 is significantly associated with immune cell infiltration, immune checkpoint expression, tumor microenvironment scores, and immunotherapy-related biomarkers like tumor mutational burden.
Conclusions:
- PLOD2 plays a significant role in tumorigenesis and cancer progression.
- PLOD2 overexpression is validated in gastric cancer via immunohistochemistry.
- PLOD2 holds potential as a promising biomarker for cancer diagnosis and prognosis.
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