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Persistence of procoagulable thromboelastography results in hospitalized COVID-19 patients despite clinical

S M Stuart1, C D Treager, T R Lopachin

  • 1Department of Emergency Medicine, Transitional Year Internship Program, Naval Medical Readiness Training Command, Portsmouth, VA, USA. Emily.Friedrich@gdit.com.

European Review for Medical and Pharmacological Sciences
|May 19, 2022
PubMed

Insights

COVID-19 patients exhibit persistent blood hypercoagulability, indicated by abnormal thromboelastography (TEG) results even after clinical improvement. This suggests a prolonged risk for blood clots (thromboembolic events) warrants further study.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 is associated with a hypercoagulable state, increasing the risk of thromboembolic events.
  • Understanding the dynamics of blood coagulation in hospitalized COVID-19 patients is crucial for risk assessment.

Purpose of the Study:

  • To monitor the kinetics of blood coagulation in COVID-19 patients throughout their hospitalization.
  • To assess the persistence of prothrombotic states upon hospital discharge.

Main Methods:

  • A prospective cohort study involving 48 adult COVID-19 patients.
  • Thromboelastography (TEG) was used daily to assess blood coagulation.
  • National Early Warning Scores (NEWS) were used to evaluate clinical risk.

Main Results:

  • 98% of patients showed procoagulable TEG results during hospitalization.
  • 80% of patients remained prothrombotic upon discharge, despite clinical improvement.
  • NEWS scores significantly decreased by discharge.

Conclusions:

  • Hospitalized COVID-19 patients exhibit persistent prothrombotic states, as evidenced by abnormal TEG results at discharge.
  • While clinical scores improved, coagulation abnormalities persisted, indicating a potential for ongoing thromboembolic risk.
  • Further investigation is needed to determine the duration and implications of this persistent hypercoagulability.
Abstract

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