Automated grading of diabetic retinopathy using CNN with hierarchical clustering of image patches by siamese network

Diabetic retinopathy (DR) is a progressive vascular complication that affects people who have diabetes. This retinal abnormality can cause irreversible vision loss or permanent blindness; therefore, it is crucial to undergo frequent eye screening for early recognition and treatment. This paper proposes a feature extraction algorithm using discriminative multi-sized patches, based on deep learning convolutional neural network (CNN) for DR grading. This comprehensive algorithm extracts local and global features for efficient decision-making. Each input image is divided into small-sized patches to extract local-level features and then split into clusters or subsets. Hierarchical clustering by Siamese network with pre-trained CNN is proposed in this paper to select clusters with more discriminative patches. The fine-tuned Xception model of CNN is used to extract the global-level features of larger image patches. Local and global features are combined to improve the overall image-wise classification accuracy. The final support vector machine classifier exhibits 96% of classification accuracy with tenfold cross-validation in classifying DR images.