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Updated: Sep 22, 2025

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Synthesis and Characteristics of Self-Assembled Multifunctional Ln3+ -DNA Hybrid Coordination Polymers
Qingzhi Han1, Xinlian Zhang1, Yijing Jia1
1Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Abstract:
Owing to the unique catalytic, optical and magnetic properties, lanthanides (Ln) as multicomponent biomarkers, are widely used in the field of optical sensing, mass spectrometry and magnetic resonance imaging. As ligands, DNA molecules have good biocompatibility, high stability, cost efficiency, programmability and biodegradability. Based on the coordination-driven self-assembly between Ln ions (Ln3+ ) and DNA molecules, a multifunctional Ln3+ -DNA hybrid coordination polymers (CPs) were synthesized. Not only a series of different Ln3+ (single Ln3+ ) and DNA hybrid CPs were synthesized, but one hybrid CP contains two kinds of Ln3+ was obtained. Besides, the synthetic CPs in cell fluorescence imaging and miRNA sensing also exhibited high performance. This work provides a novel idea for the synthesis of DNA based nanomaterials, which is promising for biologically-related applications.
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