Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systematic review on using intervention mapping to guide behavioral interventions for improving stroke patient outcomes.

Frontiers in medicine·2026
Same author

Flooded cultivation improves grain yield and appearance quality while reducing nutritional quality in Shanlan upland rice (Oryza sativa L.).

Food chemistry·2026
Same author

Simulated Natural Nanoparticles in Bai-Hu-Tang Decoction: Preparation, Characterization, Pharmacokinetics, and Antipyretic Effects.

Current topics in medicinal chemistry·2026
Same author

REACT (Real-world Emulated Clinical Trials): A Framework for Drug Repurposing Applied to Osteoporotic Fractures.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026
Same author

Optical communication based on tunable intensity vortex arrays.

Optics express·2026
Same author

Electrical Bandgap Evolution and Carrier-Induced Transport Regimes in Ultrathin PtSe<sub>2</sub>.

Nano letters·2026

Related Experiment Video

Updated: Sep 22, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

12.9K

NIR Responsive Injectable Nanocomposite Thermogel System Against Osteosarcoma Recurrence.

Ranran Guo1, Peng Zhang2, Jianing Liu2

  • 1Department of Orthopaedics, Shenzhen Hospital, Southern Medical University, Shenzhen, 518000, P. R. China.

Macromolecular Rapid Communications
|May 19, 2022
PubMed
Summary

This study introduces a novel injectable thermogel for localized immune checkpoint blockade (ICB) therapy after surgery. This system offers controlled drug release, enhancing anti-tumor immunity and preventing cancer recurrence with improved safety.

Keywords:
cancer recurrenceinjectable thermogelsnanocompositesnear infrared

More Related Videos

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

10.0K
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

Related Experiment Videos

Last Updated: Sep 22, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

12.9K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

10.0K
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Immunotherapy

Background:

  • Immune checkpoint blockade (ICB) therapy shows promise for cancer treatment but systemic administration can cause severe side effects.
  • Local delivery systems are needed to improve the safety and efficacy of ICB therapy in postoperative cancer treatment.

Purpose of the Study:

  • To develop an injectable, near-infrared (NIR) responsive nanocomposite thermogel for localized postoperative delivery of ICB.
  • To evaluate the efficacy of this thermogel system in preventing cancer recurrence in an osteosarcoma model.

Main Methods:

  • Synthesized an injectable thermogel via copolymerization of thermosensitive and zwitterionic monomers.
  • Incorporated functional mesoporous nanoparticles for NIR-triggered heat generation and controlled ICB release via retro Diels-Alder reaction.
  • Tested the system in an osteosarcoma postsurgical recurrence model in vivo.

Main Results:

  • The thermogel demonstrated favorable biocompatibility and controlled ICB release, avoiding premature drug leakage.
  • Achieved increased drug concentration at the tumor site and enhanced T cell activation.
  • Successfully suppressed tumor recurrence in the osteosarcoma model.

Conclusions:

  • The developed injectable nanocomposite thermogel is a promising platform for localized, controlled ICB delivery in cancer postoperative therapy.
  • This approach mitigates systemic side effects and improves therapeutic outcomes by enhancing local anti-tumor immunity.