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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

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Challenges for optical nanothermometry in biological environments.

Marta Quintanilla¹, Malou Henriksen-Lacey^2,3, Carlos Renero-Lecuna^2,3

¹Materials Physics Department, Universidad Autónoma de Madrid (UAM), Avda. Francisco Tomás y Valiente, 7. 28049, Madrid, Spain. marta.quintanilla@uam.es.

Chemical Society Reviews

|May 19, 2022

Summary

Accurate temperature monitoring using nanothermometers is crucial for medical diagnosis and hyperthermia treatments. This review explores methods for reliable temperature sensing in complex tissues, addressing challenges in optical properties and light-tissue interactions.

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Area of Science:

Biomedical Engineering
Materials Science
Optical Physics

Background:

Temperature monitoring is vital for medical diagnosis and hyperthermia treatments to prevent cytotoxic effects.
Luminescent materials, or nanothermometers, are widely used for temperature sensing.
Optical properties of tissues significantly impact the accuracy of nanothermometer measurements.

Purpose of the Study:

To review methods for accurate temperature sensing using nanothermometers in heterogeneous biological environments.
To discuss recent advancements in optical (nano)thermometry.
To address challenges related to light-tissue interactions and thermal misreading.

Main Methods:

Incorporation of luminescent nanoparticles into complex in vitro and in vivo models.
Analysis of optical properties of heterogeneous tissues.
Development of strategies to avoid thermal misreading.

Main Results:

Nanothermometers offer a promising approach for temperature monitoring in complex biological settings.
Understanding and accounting for tissue optical properties are essential for accurate thermal readings.
Specific methods can mitigate inaccuracies caused by tissue heterogeneity and therapeutic alterations.

Conclusions:

Optical nanothermometry is a valuable tool for precise temperature monitoring in medical applications.
Further research is needed to optimize nanothermometer performance in diverse and dynamic biological tissues.
Strategies to overcome light-tissue interaction challenges are critical for clinical translation.