Comprehensive analysis of emerging flame retardants, a risk factor to prostate cancer?

Among man-made chemicals, flame retardants have caused great environmental concerns. Several studies in recent years have investigated potential sources of flame retardants, environmental distribution, exposure to wild animals and humans and toxicity. However, studies focusing on the prediction of toxicity of flame retardants are limited. Herein, toxicological and tumor databases were applied to evaluate the potential correlation between emerging flame retardants (EFRs) and tumors. Further analysis also showed that EFRs may be associated with prostate cancer (PCa). After constructing an EFR-related prognostic prediction model, it was established that EFR-related genes showed a strong prognostic predictive value among PCa patients. In addition, compared with the clinical characteristics model (including age, Gleason score, prostate-specific antigen level, T stage and N stage), a prognostic predictive model-based risk score demonstrated a better predictive value of PCa. The AUC of the 31-gene prognostic signature at 1, 3 and 5 years was 0.843, 0.824 and 0.819, respectively. In addition, the AUC of the risk score, Gleason score, age, PSA level, T stage and N stage were 0.843, 0.637, 0.414, 0.490, 0.668 and 0.517, respectively. Our analysis provides a comprehensive map of EFR interaction genes and demonstrated a new direction for environmentally hazardous materials and diseases.