Related Experiment Video
Updated: Sep 22, 2025

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
Published on: May 9, 2021
Why you always in a mood? Pumpin' polyP, actin' brand new
Kevin A Guttenplan1, Aaron D Gitler2
1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Abstract:
What causes neurons to die in neurodegenerative disease? In this issue of Neuron, Arredondo et al., 2022 report an unexpected culprit that may drive neuronal death in amyotrophic lateral sclerosis-an evolutionarily ancient energy-storage polymer called polyphosphate (polyP).
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