Related Experiment Video
Updated: Sep 22, 2025

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
Different methods, techniques and their limitations in protein structure prediction: A review
Vrushali Bongirwar1, A S Mokhade2
1Shri Ramdeobaba College of Engineering and Management, Nagpur, India.
Abstract:
Because of the increase in different types of diseases in human habitats, demands for designing various types of drugs are also increasing. Protein and its structure play a very important role in drug design. Therefore researchers from different areas like mathematics, medicines, and computer science are teaming up for getting better solutions in the said field. In this paper, we have discussed different methods of secondary and tertiary protein structure prediction (PSP), along with the limitations of different approaches. Different types of datasets used in PSP are also discussed here. This paper also tells about different performance measures to evaluate the prediction accuracy of PSP methods. Different software's/servers are available for download, which are used to find the protein structures for the input protein sequence. These softwares will also help to compare the performance of any new algorithm with other available methods. Details of those softwares are also mentioned in this paper.
Related Concept Videos
Protein Organization
The primary structure of a protein is its amino acid sequence....
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
Protein-protein Interfaces
Protein and Protein Structures
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...

