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Updated: Sep 22, 2025
In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
Recent developments in computational and experimental studies of physicochemical properties of Au and Ag
T Ngake1, S Nqayi1, M Gulumian2
1Department of Physics, University of the Free State, Nelson Mandela Avenue, Park West, Bloemfontein 9301, South Africa.
Abstract:
Recent developments in studies of the uptake and toxicity of both gold (Au) and silver (Ag) nanostructures (NS) in drug delivery systems have shown that physicochemical properties play an important role. Physicochemical properties of engineered NS such as size, shape, coordination chemistry, surface charge, and surface chemistry generally manifest in reactivity, surface energetics and electronic properties of the nanomaterials. This review discusses the computational and experimental studies conducted to study the effects of physicochemical properties on cellular uptake and nanostructure toxicity. The studies show that properties like coordination chemistry have often been overlooked when studying the high surface energy of NS.
