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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Increased Risk of Cardio-Cerebrovascular Diseases in Migraine Patients: A Nationwide Population-Based, Longitudinal

Seung-Jae Lee1, Seok Yoon2, Yoon-Jong Bae3

  • 1Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. neurosj@catholic.ac.kr.

Journal of Clinical Neurology (Seoul, Korea)
|May 19, 2022
PubMed

Insights

Migraine is linked to increased risks of peripheral arterial disease, ischemic heart disease, atrial fibrillation, and stroke. These associations, including cardio-cerebrovascular diseases, are notably stronger in women.

Area of Science:

  • Cardiology
  • Neurology
  • Epidemiology

Background:

  • Migraine is a neurological disorder associated with several cardio-cerebrovascular diseases (CCDs).
  • The specific links between migraine and conditions like peripheral arterial disease (PAD) and atrial fibrillation (AF) require further investigation.

Purpose of the Study:

  • To investigate the association between migraine and various CCDs, including PAD, ischemic heart disease (IHD), AF, ischemic stroke (IS), and hemorrhagic stroke (HS).
  • To compare the incidence of these CCDs in individuals with and without a history of migraine.

Main Methods:

  • Utilized the Korean National Health Insurance Service database (2002-2018) with International Classification of Diseases, Tenth Revision (ICD-10) codes.
  • Employed 1:1 propensity-score matching to create comparable migraine (n=130,050) and nonmigraine (n=130,050) cohorts.
  • Applied Cox proportional-hazards regression models to determine adjusted hazard ratios (aHRs) for CCDs in migraineurs versus controls.

Main Results:

  • Migraine patients exhibited significantly higher cumulative incidence rates for all investigated CCDs compared to non-migraine controls (p<0.001).
  • Migraine was associated with increased risks of PAD (aHR 2.29), IHD (aHR 2.17), AF (aHR 1.84), IS (aHR 2.91), and HS (aHR 2.46).
  • The associations between migraine and CCDs were consistently stronger in female patients than in male patients.

Conclusions:

  • Migraine is significantly associated with an increased risk of multiple cardio-cerebrovascular diseases.
  • The observed associations are more pronounced in women, highlighting potential sex-specific differences in migraine's impact on cardiovascular and cerebrovascular health.
Abstract

Keywords:
cardiovascular diseasescerebrovascular diseasesmigrainestroke

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