Related Experiment Video
Updated: Sep 22, 2025

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Conjugated Polymers for Gene Delivery and Photothermal Gene Expression
Gang Song1,2, Fengting Lv1, Yiming Huang1
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Abstract:
Gene therapy has attracted great attention due to its applications in disease treatment. The key point for gene therapy is how to improve the efficiency of gene delivery and precisely control gene expression. Conjugated polymers (CPs) have hydrophobic π-conjugated backbones and modifiable side chains, which provide desired photophysical properties and have been applied in the field of bio-sensing, biomedical and gene-based therapies. Herein, we summarize the strategies of DNA delivery and small interfering RNA (siRNA) delivery based on cationic conjugated polymers, in addition, the strategies for precisely control the expression of target gene by photothermal-responsive conjugated polymers for cancer therapy and gene editing are described. Finally, future challenges of efficient and safe gene delivery strategies are presented, and perspectives in the precise control of gene expression are also discussed.
Related Concept Videos
Gene Therapy
Reporter Genes

