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Ketotherapy: Cutting carbs to treat cancer
Megan D Radyk1, Samuel A Kerk2, Costas A Lyssiotis3
1Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Abstract:
Dietary interventions hold promise in cancer treatments. However, clinical application has been limited by a lack of mechanistic understanding of the metabolic effects. In this issue, Yang et al. use mouse models and isotope tracing to demonstrate that the ketogenic diet induces reductive stress and primes pancreatic tumors for chemotherapy.1.
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