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Updated: Sep 22, 2025

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Published on: September 17, 2020
Four novel genes associated with longevity found in Cane corso purebred dogs
Evžen Korec1, Lenka Ungrová2,3, Jiří Hejnar3
1Zoologická zahrada Tábor a.s., Dukelských Hrdinů 19, 170 00, Prague 7, Czech Republic. director@zootabor.eu.
Background:
Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity.
Results:
SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs.
Conclusions:
Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.
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