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Oral mRNA Vaccines Against Infectious Diseases- A Bacterial Perspective [Invited]

Vijayakumar Jawalagatti1, Perumalraja Kirthika1, John Hwa Lee1

  • 1Department of Veterinary Public Health, College of Veterinary Medicine, Jeonbuk National University, Iksan, South Korea.

Frontiers in Immunology
|May 20, 2022
PubMed

Insights

Researchers developed an oral mRNA vaccine using a Salmonella vehicle and Semliki Forest viral replicon. This innovative approach shows promise for delivering vaccines against infectious diseases like SARS-CoV-2.

Area of Science:

  • Vaccinology
  • Microbial Gene Delivery
  • Viral Replicons

Background:

  • The success of mRNA vaccines against SARS-CoV-2 highlights the potential of mRNA technology.
  • Oral vaccine delivery remains significantly underexplored, despite its advantages.
  • Salmonella-based vaccines have a history of successful development for oral administration.

Purpose of the Study:

  • To explore the development of orally administrable mRNA vaccines.
  • To investigate the use of Semliki Forest viral replicon and Salmonella for oral mRNA vaccine delivery.
  • To assess the feasibility of this approach for infectious diseases, using SARS-CoV-2 as a model.

Main Methods:

  • Exploited Semliki Forest viral replicon for transgene amplification.
  • Utilized Salmonella as a vehicle for gene delivery.
  • Developed and tested an oral replicon-based mRNA vaccine candidate.

Main Results:

  • Demonstrated the potential for oral delivery of mRNA vaccines.
  • Showcased the combined efficacy of viral replicons and bacterial vectors.
  • Provided preliminary data on SARS-CoV-2 vaccine efficacy using this novel platform.

Conclusions:

  • Oral replicon-based mRNA vaccines represent a promising new strategy for infectious disease prevention.
  • Bacterial gene delivery systems offer unique advantages for oral vaccine development.
  • Further research is warranted to explore the full potential and limitations of this technology.
Keywords:
SARS-CoV-2alphaviral repliconbacterial deliveryinfectious diseasesmRNA vaccinemucosal vaccineoral

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