Phytotherapy for Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis

Area of Science:

• Neuroscience
• Pharmacology
• Pediatrics

Background:

• Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder impacting children and adolescents.
• Traditional ADHD treatments may have side effects, leading to interest in alternative therapies.
• Herbal remedies are popular complementary and alternative medicine (CAM) options, but their efficacy and safety require investigation.

Approach:

• A systematic review was conducted to evaluate recent advancements in evidence-based herbal remedies for ADHD.
• Electronic databases and study references were searched for randomized controlled trials (RCTs) and open-label studies.
• Seven RCTs involving children and adolescents diagnosed with ADHD met the inclusion criteria.

Key Points:

• Melissa officinalis L., Bacopa monnieri (L.) Wettst., Matricaria chamomilla L., and Valeriana officinalis L. showed a fair indication of efficacy and safety for various ADHD symptoms.
• Limited evidence suggests potential benefits for Ginkgo biloba L. and pine bark extract.
• Other herbal preparations did not demonstrate significant efficacy in the reviewed studies.

Conclusions:

• While some herbal remedies show promise, current evidence is insufficient to strongly recommend them for ADHD treatment.
• More rigorous research is necessary to establish the effectiveness and safety of herbal medicines for ADHD.
• Exploring CAM options like herbal therapy for ADHD warrants further investigation to support alternative treatment approaches.