Related Experiment Video
Updated: Sep 22, 2025
09:40
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
17.9K
Primary hyperoxaluria type 1 in developing countries: novel challenges in a new therapeutic era
Neveen A Soliman1, Sameh Mabrouk2
1Department of Pediatrics, Center of Pediatric Nephrology and Transplantation, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.
Clinical Kidney Journal
|May 20, 2022
Summary
Primary hyperoxaluria type 1 (PH1) is a metabolic disorder causing excess oxalate. This review addresses diagnostic delays and treatment gaps in developing countries, advocating for equitable access to novel therapies.
Area of Science:
- Metabolic Disorders
- Genetics
- Pharmacology
Background:
- Primary hyperoxaluria type 1 (PH1) results from AGXT gene mutations, leading to hepatic oxalate overproduction.
- Diagnostic delays and management challenges are prevalent in developing countries, exacerbating healthcare disparities.
- Limited treatment options historically contrasted with emerging novel therapies.
Purpose of the Study:
- To review the current state of PH1 in developing countries.
- To analyze accessibility challenges and benefits of novel therapeutics for PH1.
- To propose an integrated approach for equitable access to sustainable PH1 treatments.
Main Methods:
- Literature review on PH1 epidemiology, diagnosis, and management in developing countries.
- Analysis of novel therapeutic agents and their accessibility.
- Discussion of strategies for personalized medicine and reduced healthcare disparities.
Main Results:
- Significant diagnostic delays and management gaps exist for PH1 in developing countries.
- Novel therapies offer potential to improve outcomes but face accessibility hurdles.
- An integrated, personalized approach is crucial for equitable treatment access.
Conclusions:
- Addressing PH1 disparities requires focused strategies for developing countries.
- Equitable access to novel therapeutics can bridge the care gap.
- Personalized medicine and sustainable treatments are key to improving global PH1 care.
Related Concept Videos
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
43
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
43
01:28Chronic Kidney Disease III: Interprofessional Care
89
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
89
01:30Urinary Tract Calculi III: Medical Management
39
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
39
01:20Acute Kidney Injury V: Interprofessional Care
52
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
52
01:24Renal Tubule and Collecting Duct
1.6K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.6K
01:18Chronic Kidney Disease IV: Nursing Management
63
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
63