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Primary hyperoxaluria: the pediatric nephrologist's point of view
Efrat Ben-Shalom1, Sander F Garrelfs2, Jaap W Groothoff2
1Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel.
Abstract:
The clinical presentation of primary hyperoxaluria in children ranges from mildly symptomatic nephrocalcinosis to very early onset end-stage kidney failure with systemic oxalosis, a devastating complication. We review the various manifestations of pediatric hyperoxaluria, treatment options for children with preserved kidney function and appropriate dialysis regimens. Liver or combined liver/kidney transplantation is currently the only definitive treatment for primary hyperoxaluria type 1, but novel RNA interference treatments offer hope for the future. Finally, we address the medical and ethical dilemmas facing pediatricians treating children with hyperoxaluria.
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