Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-performance photothermal GA-MoSe<sub>2</sub> nanosheet for rapid and sensitive point-of-care detection of C-reactive protein.

Journal of nanobiotechnology·2026
Same author

Biocompatible semiconducting molybdenum diselenide nanosheets with glycyrrhizic acid for enhanced photothermal cancer therapy.

Colloids and surfaces. B, Biointerfaces·2026
Same author

pH-Responsive Multicomponent Nanocomposite for Enhanced Reactive Oxygen Species Generation and Targeted Apoptosis-Induced Synergistic Cancer Treatment.

Advanced healthcare materials·2025
Same author

Fucoidan-chitosan nanocarriers for anticancer therapy through chemodynamic, photothermal, and glucose starvation strategies.

Colloids and surfaces. B, Biointerfaces·2025
Same author

Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems.

Light, science & applications·2025
Same author

Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University·2025

Related Experiment Video

Updated: Sep 22, 2025

Generation of Alginate Microspheres for Biomedical Applications
10:33

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

21.1K

Alginate-based Composite Microspheres: Preparations and Applications for Bone Tissue Engineering.

Venkatesan Jayachandran1,2, Sesha Subramanian Murugan2, Pandurang Appana Dalavi2

  • 1Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan 426-791, South Korea.

Current Pharmaceutical Design
|May 20, 2022
PubMed
Summary
This summary is machine-generated.

Alginate microspheres show promise for bone tissue engineering, offering biocompatibility and controlled delivery for regeneration. Preclinical studies confirm their potential as graft substitutes for bone repair.

Keywords:
Alginatebone tissue engineeringchitosanmesenchymal stem cellsmicrospheresregenerative medicine

More Related Videos

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.0K
Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

3.0K

Related Experiment Videos

Last Updated: Sep 22, 2025

Generation of Alginate Microspheres for Biomedical Applications
10:33

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

21.1K
Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.0K
Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

3.0K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Alginate is a biocompatible and biodegradable polymer extensively used in developing scaffolds, microspheres, and hydrogels for bone tissue engineering.
  • Alginate microspheres offer versatile applications due to their ability to deliver growth factors and drugs, with production methods including crosslinking, microfluidics, 3D printing, extrusion, and emulsion.

Purpose of the Study:

  • To review the chemical characterization and mechanical properties of alginate-based microspheres.
  • To analyze the combination of alginate with various materials and bioactive agents for bone repair and regeneration.
  • To assess the biocompatibility and preclinical efficacy of alginate microspheres in vivo for bone tissue engineering.

Main Methods:

  • Literature review focusing on chemical characterization, mechanical assessment, and composite formulations of alginate microspheres.
  • Analysis of alginate combinations with materials like hydroxyapatite, chitosan, and bioglass.
  • Evaluation of alginate microspheres incorporating growth factors, cells, and drugs for bone regeneration.

Main Results:

  • Alginate microspheres can be produced in sizes ranging from 10 μm to 4 mm using various fabrication techniques.
  • Combinations with materials (e.g., hydroxyapatite, chitosan) and bioactive agents (e.g., BMPs, VEGF) enhance bone regeneration potential.
  • Preclinical in vivo studies demonstrate the efficacy of alginate microspheres as potential graft substitutes for bone repair.

Conclusions:

  • Alginate-based microspheres are highly promising for bone tissue engineering applications.
  • Their versatility in formulation and delivery systems supports their use in bone repair and regeneration.
  • Further preclinical research validates their potential for treating bone-related diseases and as graft substitutes.