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Updated: Sep 22, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer's Disease: Long Road Ahead
Yuxuan Dai1, Chenyi Lei2, Zhenhao Zhang1
1Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Academician Workstation of Chen Zhi-nan Medical University, Xi'an Medical University, Xi'an 710021, China.
Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline. The obvious pathological features of AD are still amyloid plaques and neurofibrillary tangles. Development of disease-modifying treatments for AD has been challenging, with almost all drugs aborted. The amyloid cascade concept has been questioned due to the failures of various amyloid-targeting prospects. Despite this, targeting amyloid-β (Aβ) active immunotherapy provided some positive results to support this hypothesis and clinical trials of these candidates are ongoing. In this review, we describe the latest advance in therapeutic strategies based on amyloidogenic processing and evaluate the pros and cons of each treatment strategy. We also highlight the current status of the hottest immunotherapy and discuss the future development direction.
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