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Major adverse cardiovascular events in bulgarian patients with chronic coronary syndrome

B Stoimenov1, R Pancheva1, S Dineva2

  • 1Department of Cardiology, Medical University, University Hospital Alexandrovska, Clinic of Propedeutics of Internal Diseases, Sofia, Bulgaria.

Nigerian Journal of Clinical Practice
|May 20, 2022
PubMed

Insights

Coronary artery calcium score (CACS) and specific risk factors predict major adverse cardiovascular events (MACEs) in chronic coronary syndrome patients. Different risk profiles are associated with MACEs across CACS groups.

Area of Science:

  • Cardiology
  • Preventive Cardiology
  • Cardiovascular Imaging

Background:

  • Primary prevention of atherosclerotic cardiovascular disease relies on risk assessment for risk factor modification.
  • Chronic coronary syndrome management requires understanding prognostic factors.

Purpose of the Study:

  • To analyze the prognostic role of risk factors, comorbidities, and coronary artery calcium score (CACS) for major adverse cardiovascular events (MACEs).
  • To investigate MACE predictors in Bulgarian patients with chronic coronary syndrome.

Main Methods:

  • Observational study of 214 patients with chronic coronary syndrome.
  • Patients categorized into three groups based on CACS: 0, 1-400, and >400 Agatston units (AU).
  • Cox proportional hazard regression analysis used for prognostic assessment over a 3.8-year follow-up.

Main Results:

  • In the CACS=0 group, elevated low-density lipoprotein and paroxysmal atrial fibrillation significantly increased MACE rates.
  • In the CACS 1-400 group, increased coronary calcium volume, aortic valve calcification, and left ventricular mass were associated with higher MACE incidence.
  • Specific risk factors demonstrated significant hazard ratios for MACE development across different CACS strata.

Conclusions:

  • Different risk factors are associated with increased MACE rates in patients with chronic coronary syndrome across varying CACS levels.
  • Coronary artery calcium scoring provides valuable prognostic information beyond traditional risk factors.
Abstract

Keywords:
Atherosclerotic cardiovascular diseasecalcium scorechronic coronary syndromemajor adverse cardiovascular events

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