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Immune-based therapeutic approaches in COVID-19
Aysan Moeinafshar1, Niloufar Yazdanpanah2, Nima Rezaei3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Insights
This review explores immune-based therapies for COVID-19, examining treatments like corticosteroids and monoclonal antibodies. It highlights the immune system
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, was declared a pandemic by the WHO in March 2020.
- While risk reduction and vaccination are key, diverse treatments are being developed.
- The immune system's dual role in pathogen elimination and causing complications like cytokine storm syndrome makes it a therapeutic target.
Purpose of the Study:
- To conduct a comprehensive review of immune-based therapeutic strategies for COVID-19.
Main Methods:
- Literature review of immune-based treatments for COVID-19.
- Analysis of therapeutic approaches including corticosteroids, IVIG, interferon therapy, and anti-SARS-CoV-2 monoclonal antibodies.
Main Results:
- Immune-based therapies are a significant area of COVID-19 research.
- Various immune-modulating agents and specific antibody treatments have been investigated.
Conclusions:
- Immune-based approaches offer potential for managing COVID-19.
- Further research into these therapies is warranted to combat the disease effectively.
Abstract:
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a member of the Coronaviridae family. On March 11, 2020 the World Health Organization (WHO) has named the newly emerged rapidly-spreading epidemic as a pandemic. Besides the risk-reduction measures such as physical and social distancing and vaccination, a wide range of treatment modalities have been developed; aiming to fight the disease. The immune system is known as a double-edged sword in COVID-19 pathogenesis, with respect to its role in eliminating the pathogen and in inducing complications such as cytokine storm syndrome. Hence, immune-based therapeutic approaches have become an interesting field of COVID-19 research, including corticosteroids, intravenous immunoglobulins (IVIG), interferon therapy, and more COVID-19-specific approaches such as anti-SARS-CoV-2-monoclonal antibodies. Herein, we did a comprehensive review on immune-based therapeutic approaches for COVID-19. DATA AVAILABILITY STATEMENT: Not applicable.
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