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Related Experiment Video

Updated: Sep 22, 2025

A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
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Silica nanoparticles: Biomedical applications and toxicity.

Yanmei Huang1, Peng Li2, Ruikang Zhao1

  • 1School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 20, 2022
PubMed
Summary

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Articles linked to this work by shared authors, journal, and citation graph.

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[Analysis of clinical characteristics of renal oncocytoma: 26 cases report].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2012
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Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

International journal of molecular sciences·2012
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[Analysis of genes and genetic susceptibility of olfactory disorders].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2012
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Silica nanoparticles (SiNPs) offer promising biomedical applications for disease diagnosis and treatment. However, further research is crucial to understand their potential toxicity mechanisms in the human body.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Silica nanoparticles (SiNPs), derived from silicon dioxide, are versatile materials with controllable size, large surface area, and biocompatibility.
  • Their applications span diverse fields, including food, synthesis, medical diagnostics, and drug delivery.
  • Economical synthesis strategies have been developed, facilitating widespread research.

Purpose of the Study:

  • To review recent advancements in the biomedical applications of SiNPs.
  • To comprehensively discuss the in vitro and in vivo toxicity of SiNPs.
  • To explore the underlying toxicity mechanisms and their impact on human systems.

Main Methods:

  • Literature review of recent studies on SiNP biomedical applications.
Keywords:
Biomedical applicationsDiagnosisDrug deliverySilica nanoparticlesSynthetic methodsToxicity

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  • Analysis of research on SiNP surface and structural modifications for targeted therapies.
  • Examination of studies investigating SiNP toxicity across various human organs and systems.

    • Main Results:

    • SiNPs show significant potential in drug delivery systems for diagnosing and treating various diseases.
    • Current understanding of SiNP toxicity and its mechanisms remains limited and requires further investigation.
    • Research is progressing towards practical applications, but toxicity assessments are still in early stages.

    Conclusions:

    • SiNPs hold considerable promise for future medical advancements.
    • Thorough evaluation of SiNP safety and toxicity is essential before widespread clinical adoption.
    • Continued research into SiNP interactions with biological systems will pave the way for their responsible development.