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Strontium-loaded titanium-15molybdenum surface improves physicochemical and biological propertiesin vitro
Flávia Gomes Matos1, Luís Carlos Leal Santana1, Mariana Aline Cominotte1
1Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University-UNESP, Araraquara, SP, Brazil.
Biomedical Physics & Engineering Express
|May 20, 2022
Summary
Strontium loading on etched Ti-15Mo alloy enhances surface properties and promotes bone cell adhesion and proliferation. This surface modification improves osseointegration potential for biomedical implants.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Cell Biology
Background:
- Osseointegration, crucial for dental and orthopedic implants, depends on the interaction between implant materials and bone cells.
- Titanium alloys, like Ti-15Mo, are widely used but their surface properties can be modified to enhance biological responses.
- Surface treatments aim to improve biocompatibility, electrochemical stability, and cellular interactions for better implant integration.
Purpose of the Study:
- To evaluate the impact of phosphoric acid (H3PO4) and sodium hydroxide (NaOH) treatments followed by strontium (Sr) loading on the physicochemical and electrochemical properties of Ti-15Mo alloy.
- To assess the metabolic response, including adhesion, proliferation, and spreading, of MC3T3-E1 pre-osteoblast cells on the modified Ti-15Mo surfaces.
- To investigate the potential of Sr deposition via hydrothermal method to enhance osseointegration.
Main Methods:
- Ti-15Mo alloy discs were treated with H3PO4 and NaOH, followed by hydrothermal strontium (Sr) loading.
- Surface characterization included X-ray dispersive energy spectroscopy (EDS), X-ray diffraction (XRD), and confocal laser scanning microscopy (CLSM).
- Electrochemical stability was assessed, and cell responses (metabolic activity, adhesion, proliferation) were evaluated using AlamarBlue and fluorescence assays. Inductively coupled plasma optical emission spectrometry (ICP-OES) quantified Sr retention.
Main Results:
- Strontium-loaded samples exhibited increased surface roughness and improved surface free energy and corrosion resistance after acid/alkali etching.
- Hydrothermal Sr deposition resulted in significant retention of Sr particles on the Ti-15Mo surface.
- MC3T3-E1 cells showed non-cytotoxic responses, with enhanced adhesion, proliferation, and spreading on Sr-loaded surfaces compared to controls.
Conclusions:
- Acid/alkali etching combined with hydrothermal Sr deposition effectively modifies the Ti-15Mo alloy surface.
- The modified surface demonstrates improved physicochemical properties and electrochemical stability.
- Strontium loading enhances cellular responses, indicating a promising strategy for improving osseointegration in biomedical applications.
