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Updated: Sep 22, 2025

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
Published on: June 7, 2017
Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells
Jessica K Mandula1, Paulo C Rodriguez1
1Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Abstract:
In this issue of Cancer Cell, Long et al. demonstrate that tumors can reprogram erythroid progenitors into myeloid-erythroid cells that promote immunosuppression. Erythroid-differentiated myeloid cells (EDMCs) expand in cancer-bearing individuals, resemble the functionality of myeloid-derived suppressor cells (MDSCs), and correlate with poor response to immune-checkpoint inhibitors (ICIs) and tumor-related anemia.
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