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Updated: Sep 22, 2025
07:59
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Naturally occurring dimeric triterpenoids: Occurrence, chemistry and bioactivities
Gervais Mouthé Happi1, Virginia Kien Ntabo1, Alain Tadjong Tcho2
1Department of Chemistry, Higher Teacher Training College, The University of Bamenda, P.O Box 39, Bambili, Cameroon.
Phytochemistry
|May 20, 2022
Summary
Triterpene dimers are specialized plant metabolites with diverse structures and biological activities. This review compiles information on their occurrence, chemistry, and known bioactivities, aiding further research.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Triterpenes are abundant specialized metabolites in plants, known for their protective roles and diverse biological activities.
- Triterpene dimers, a specific subclass, exhibit significant structural diversity and potential pharmacological properties.
- Despite their prevalence, the chemical and biological evaluation of triterpene dimers remains limited.
Purpose of the Study:
- To comprehensively review the existing literature on triterpenoid dimers.
- To consolidate information regarding the occurrence, chemical structures, and biological activities of these compounds.
- To facilitate further research by providing accessible information on triterpene dimers.
Main Methods:
- A systematic literature search was conducted across major scientific databases (Scifinder, PubMed, Web of Science, Google Scholar).
- Keywords used included 'terpene', 'triterpene', 'dimer', and 'celastroloid' without language restrictions.
- Information on natural and synthetic triterpene dimers reported up to 2021 was compiled.
Main Results:
- The literature search identified 90 natural and 11 synthetic triterpene dimers from 19 plant species.
- A limited number of these compounds have been evaluated for biological activities such as antibacterial, antioxidant, antiproliferative, and molluscicidal effects.
- This review synthesizes the available data on their chemical characteristics and bioactivities.
Conclusions:
- Triterpene dimers represent a promising class of natural products with potential therapeutic applications.
- Further research is needed to explore the full spectrum of biological activities and chemical diversity of triterpene dimers.
- This compilation serves as a valuable resource for researchers in natural product chemistry and drug discovery.
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