Related Experiment Video

Updated: Sep 22, 2025

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.2K

Evolution and Prognostic Impact of Cardiac Damage After Aortic Valve Replacement

Philippe Généreux1, Philippe Pibarot2, Björn Redfors3

  • 1Gagnon Cardiovascular Institute, Morristown Medical Center, Morristown, New Jersey, USA.

Journal of the American College of Cardiology
|May 20, 2022
PubMed

Insights

Aortic valve replacement (AVR) impacts cardiac damage progression. Worsening cardiac damage post-AVR independently predicts higher mortality and heart failure risk, emphasizing early intervention for better prognosis.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Interventional Cardiology

Background:

  • The effect of aortic valve replacement (AVR) on extravalvular cardiac damage progression and its prognostic significance remains unclear.
  • Understanding these changes is crucial for optimizing patient outcomes after AVR.

Purpose of the Study:

  • To investigate the evolution of cardiac damage following AVR.
  • To determine the association between changes in cardiac damage and patient prognosis.

Main Methods:

  • Pooled data from the PARTNER 2 and 3 trials included patients undergoing transcatheter or surgical AVR.
  • Cardiac damage was staged at baseline and 1 year post-AVR.
  • Proportional hazards models assessed the link between cardiac damage changes and 2-year outcomes.

Main Results:

  • Among 1,974 patients, baseline cardiac damage varied, with most in stage 2 (51.4%).
  • At 1 year, cardiac damage improved in ~15%, remained stable in ~60%, and worsened in ~25% of patients.
  • One-year changes in cardiac damage independently predicted 2-year mortality (HR worsening: 1.95) and death/heart failure hospitalization (HR worsening: 2.25).

Conclusions:

  • The extent of extravalvular cardiac damage and its change post-AVR are significant prognostic indicators.
  • Earlier detection and intervention for aortic stenosis may prevent irreversible cardiac damage, improving global cardiac function and outcomes.
Abstract

Keywords:
aortic stenosisaortic valveaortic valve replacementcardiac damageprognosisstagingtranscatheter aortic valve implantationtranscatheter aortic valve replacementvalve disease

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.5K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
53
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
62
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
56
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
67
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
49
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
57