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CD98hc in host-pathogen interactions: roles of the multifunctional host protein during infections

Sonia Vection1,2, David O'Callaghan1,2, Anne Keriel1,2

  • 1VBIC, U1047 INSERM, Université de Montpellier, Nîmes, France.

FEMS Microbiology Reviews
|May 20, 2022
PubMed

Insights

The eukaryotic protein CD98hc (also known as SLC3A2) is crucial for various infections. This review details its role in bacterial, viral, and apicomplexan pathogenesis.

Area of Science:

  • Cell Biology
  • Immunology
  • Infectious Diseases

Background:

  • CD98hc (SLC3A2) is a membrane glycoprotein forming heterodimeric amino acid transporters.
  • It plays roles in integrin signaling, immune development, and tumorigenesis.
  • CD98hc is implicated in host-pathogen interactions.

Purpose of the Study:

  • To review the role of CD98hc and its light chains in infectious diseases.
  • To discuss the impact of infections on CD98hc expression and localization.
  • To highlight CD98hc's significance in pathogenesis.

Main Methods:

  • Literature review of studies on CD98hc in infectious diseases.
  • Analysis of CD98hc's involvement in viral, bacterial, and apicomplexan pathogenesis.
  • Examination of infection-induced changes in CD98hc expression and localization.

Main Results:

  • CD98hc mediates numerous viral, apicomplexan, and bacterial infectious processes.
  • Infections alter the expression and localization of CD98hc and its associated light chains.
  • CD98hc is a key host factor in pathogen invasion and replication.

Conclusions:

  • CD98hc is a critical host protein in infectious disease pathogenesis.
  • Understanding CD98hc's functions offers insights into host-pathogen interactions.
  • Targeting CD98hc may present therapeutic strategies against infections.

Keywords:
CD147CD98hcLAT1SLC3A2amino acid transportinfectionxCT

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