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Like Visiting an Old Friend: Fischer Glycosylation in the Twenty-First Century: Modern Methods and Techniques
Matteo Haese1, Kai Winterhalter1, Jessica Jung1
1Institute of Precision Medicine, Organic and Bioorganic Chemistry Labs, Medical and Life Sciences Faculty, Furtwangen University, Jakob-Kienzle-Str. 17, 78054, VS-Schwenningen, Germany.
Abstract:
Fischer glycosylation is typically the chemical reaction of a monosaccharide and an alcohol in presence of an acidic catalyst to afford glycosides in pyranosidic and furanosidic forms. This reaction is still applied today for the synthesis of specialized glycosides, and optimization and modification of the method have continued since its discovery by Emil Fischer in the 1890s. This review presents advancements in Fischer glycosylation described in literature of the past 15 years and its implementation in modern chemical methods.
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