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Updated: Sep 22, 2025
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
Stefano Lazzi1, Massimo Granai2, Marco Capanni3
1Department of Medical Biotechnology, University of Siena, Siena, Italy. lazzi2@unisi.it.
Background:
To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion.
Case Presentation:
A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion.
Conclusions:
A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach.
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