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Updated: Sep 22, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Microgel-Based Thermosensitive MRI Contrast Agent.

Xinwei Zheng¹, Junchao Qian¹, Fei Tang¹

¹High Magnetic Field Laboratory, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Hefei 230031, P. R. China.

ACS Macro Letters

|May 21, 2022

Summary

This summary is machine-generated.

This study introduces a novel thermosensitive microgel contrast agent for MRI. The agent effectively monitors subtle temperature changes by altering MRI signal intensity around the lower critical solution temperature (LCST).

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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Area of Science:

Biomedical Engineering
Materials Science
Radiology

Background:

Noninvasive monitoring of subtle temperature changes using Magnetic Resonance Imaging (MRI) presents a significant challenge.
Developing sensitive contrast agents is crucial for advancing MRI-based temperature mapping.

Purpose of the Study:

To synthesize and characterize novel thermosensitive microgels as MRI contrast agents for temperature monitoring.
To evaluate the temperature-dependent changes in MRI longitudinal relaxivity (r1) of the synthesized microgels.

Main Methods:

Synthesized manganese porphyrin-based thermosensitive microgels using N-isopropylacrylamide (NIPAM) or N-isopropylmethacrylamide (NIPMAM) monomers.
Investigated microgel volume changes around their lower critical solution temperatures (LCST).
Measured MR longitudinal relaxivity (r1) changes in response to temperature variations.

Main Results:

NIPAM-incorporated microgel (M-1) exhibited a sharp volume decrease around its LCST (29-33 °C) and a 44% r1 enhancement.
NIPMAM-incorporated microgel (M-2) showed a gradual volume decrease and smaller r1 changes.
Optimized M-1 (M-3) without cross-linkers demonstrated a 67% r1 increase around its LCST.

Conclusions:

Microgel volume changes around the LCST strongly modulate longitudinal relaxivity, enabling sensitive temperature detection.
The developed thermosensitive microgels show potential as novel contrast agents for precise MRI-based temperature monitoring.