Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Selective-Transport Elastomeric Coating Regulating Hierarchical Solid Electrolyte Interphase for Low-Temperature Lithium-Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Development and validation of diagnostic prediction models for central precocious puberty in girls based on machine learning: a multicenter retrospective study.

Frontiers in endocrinology·2026
Same author

Algorithm-hardware co-design of neuromorphic networks with dual memory pathways.

Nature machine intelligence·2026
Same author

Context-dependent short-chain fatty acids in inflammatory skin diseases: Immunometabolic mechanisms, evidence boundaries, and translational perspectives.

Pharmacological research·2026
Same author

Closed-Loop Chemically Recyclable Separation Membranes With Superior Pervaporation Performance.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children.

Frontiers in medicine·2026

Related Experiment Video

Updated: Sep 22, 2025

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

7.4K

Photoswitchable Nanocarrier with Reversible Encapsulation Properties.

Peng-Fei Cao1, Zhe Su1, Al de Leon1

  • 1Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.

ACS Macro Letters
|May 21, 2022
PubMed
Summary

This study introduces a novel photoswitchable dendritic polymer, polyethylenimine-steric ester-azobenzene (PEI-STA-AZO). This polymer exhibits light-controlled reversible encapsulation of anionic guests, acting as a "photo-switch" for guest-host systems.

More Related Videos

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.1K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K

Related Experiment Videos

Last Updated: Sep 22, 2025

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

7.4K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.1K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K

Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Dendritic polymers offer unique architectures for advanced applications.
  • Photoswitchable molecules can control material properties with light.
  • Developing novel guest-host systems with tunable encapsulation is crucial.

Purpose of the Study:

  • To synthesize and characterize an amphiphilic dendritic polymer incorporating photoswitchable azobenzene groups.
  • To investigate the light-induced reversible encapsulation of anionic guests by the synthesized polymer.
  • To elucidate the mechanism behind the polymer's photo-responsive guest-host behavior.

Main Methods:

  • Synthesis of polyethylenimine-steric ester-azobenzene (PEI-STA-AZO) via amidation.
  • Characterization using 1H NMR, FT-IR spectroscopy, and dynamic light scattering (DLS).
  • Encapsulation tests under alternating UV and visible-light irradiation; molecular modeling using Spartan.

Main Results:

  • The synthesized PEI-STA-AZO polymer demonstrated reversible isomerization of azobenzene moieties upon light exposure.
  • The polymer showed light-dependent encapsulation: unable to encapsulate anionic guests in the trans-isomer state but capable in the cis-isomer state.
  • Molecular modeling provided insights into the encapsulation mechanism, highlighting the role of azobenzene groups as photo-switches.

Conclusions:

  • Azobenzene groups act as effective reversible photo-switches in the dendritic guest-host system.
  • The PEI-STA-AZO polymer exhibits controllable and reversible encapsulation of anionic guests.
  • This research presents a promising platform for light-responsive materials in separation and delivery applications.