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Updated: Sep 22, 2025
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Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
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Epilepsy in neurodegenerative diseases.
Sabrina Neri1, Giovanni Mastroianni2, Elena Gardella3
1Danish Epilepsy Centre, Dianalund, Denmark, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
Summary
Epilepsy is an underrecognized comorbidity in neurodegenerative disorders. This review details clinical features, diagnosis, and treatment for epilepsy in conditions like Alzheimer's and Parkinson's disease.
Area of Science:
- Neurology
- Neuroscience
- Clinical Medicine
Background:
- Epilepsy is an increasingly recognized comorbidity in neurodegenerative disorders, yet its incidence and specific features remain poorly defined.
- Aging populations and improved healthcare lead to more elderly individuals with neurodegenerative conditions and epilepsy.
- Neurologists will increasingly encounter epilepsy as a comorbidity in neurodegenerative diseases.
Purpose of the Study:
- To provide an updated overview of epilepsy in common neurodegenerative disorders.
- To detail clinical features, pathophysiological mechanisms, and diagnostic and treatment strategies.
- To equip neurologists and epileptologists with tools for managing this comorbidity.
Main Methods:
- Review of current literature on epilepsy in neurodegenerative disorders.
- Synthesis of information on clinical presentation, pathophysiology, diagnosis, and treatment.
- Focus on Alzheimer disease, other dementias, Parkinson disease, Down syndrome, prion diseases, and progressive myoclonus epilepsies.
Main Results:
- Epilepsy incidence in neurodegenerative disorders is underestimated.
- Distinct clinical features and pathophysiological mechanisms of epilepsy vary across different neurodegenerative conditions.
- Current diagnostic and treatment approaches require tailored strategies for these complex cases.
Conclusions:
- Epilepsy is a significant and growing comorbidity in neurodegenerative disorders.
- A comprehensive understanding of epilepsy's features and management in these conditions is crucial for clinicians.
- This review serves as a valuable resource for neurologists and epileptologists managing patients with comorbid epilepsy and neurodegeneration.
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