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Association between insulin-like growth factor-1 and cardiovascular events: a systematic review and dose-response

T Li1, Y Zhao1, X Yang1

  • 1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.

Journal of Endocrinological Investigation
|May 21, 2022
PubMed

Insights

Higher insulin-like growth factor-1 (IGF-1) levels are associated with a reduced risk of cardiovascular (CV) events. This meta-analysis suggests IGF-1 is a helpful biomarker for predicting and preventing CV events.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Biomarker Research

Background:

  • Inconsistent findings link insulin-like growth factor-1 (IGF-1) to cardiovascular (CV) events.
  • A quantitative assessment through meta-analysis was lacking.

Approach:

  • A meta-analysis of 11 cohort studies (22,995 participants, 3040 CV events) was conducted.
  • Searched PubMed, Embase, and Web of Science databases up to December 1, 2020.
  • Used fixed/random-effects models and restricted cubic splines for analysis.

Key Points:

  • Higher IGF-1 levels correlated with a 16% reduction in overall CV events.
  • A 28% reduction in CV event occurrence was observed with higher IGF-1.
  • Linear associations found; each 45 μg/mL IGF-1 increase lowered CV event risk by 9%.

Conclusions:

  • Increased IGF-1 levels are beneficial in reducing overall cardiovascular event risk.
  • IGF-1 shows promise as a prognostic biomarker for cardiovascular event assessment and prevention.
Abstract

Keywords:
Cardiovascular eventsCohort studyDose–responseInsulin-like growth factor-1Meta-analysis

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