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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Ventricular systolic dysfunction in dogs diagnosed with hypoadrenocorticism.

T Gunasekaran1, R A Sanders2

  • 1Bluepearl Veterinary Partners, 4126 Packard Road, Ann Arbor, Michigan, 48108, USA.

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
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Summary

Hypoadrenocorticism in dogs can cause secondary dilated cardiomyopathy, similar to humans. This heart condition resolved in three dogs with steroid replacement therapy, suggesting a crucial link.

Keywords:
Addison's diseaseCardiomyopathyReversible

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Area of Science:

  • Veterinary Cardiology
  • Canine Endocrinology

Background:

  • Dilated cardiomyopathy in humans with hypoadrenocorticism resolves with steroid therapy.
  • A similar cardiac condition in dogs with hypoadrenocorticism has not been previously documented.

Observation:

  • Three dogs presented with concurrent hypoadrenocorticism and ventricular dilation with systolic dysfunction.
  • Two dogs exhibited signs of biventricular congestive heart failure; one presented with acute hypoadrenocorticism symptoms.

Findings:

  • All affected dogs showed complete recovery of cardiac size and function following treatment.
  • Hypoadrenocorticism is a potential underlying cause of ventricular dilation and systolic dysfunction in dogs.

Implications:

  • Consider hypoadrenocorticism in dogs with unexplained ventricular dilation and systolic dysfunction, especially with supporting clinical or laboratory findings.
  • Cardiac evaluation is recommended for dogs diagnosed with hypoadrenocorticism, particularly if a heart murmur is present.