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Molecular biology exploration and targeted therapy strategy of Ameloblastoma
Yiwen Lu1, Xudong Zhang1, Xiangjun Li1
1Department of Oral & Maxillofacial Surgery, College and Hospital of Stomatology, Hebei Medical University, The Key Laboratory of Stomatology, Hebei Province, China.
Objective:
This article aims to systematically and comprehensively discuss molecular biology-related progress and targeted therapeutic strategies for ameloblastoma, which are expected to be helpful for the diagnosis and treatment of ameloblastoma.
Design:
A comprehensive review of scientific literature relevant to ameloblastoma, including the latest classification, global epidemiology, molecular biology advances, and targeted therapy.
Results:
Among the 156 articles cited, a total of 20 non-coding RNAs, 13 genes, 27 proteins, and 8 pathways were involved, which play a variety of roles in ameloblastoma. These roles include participation in the biological behaviours of ameloblastoma migration, differentiation, and apoptosis; detection of ameloblastoma proliferative properties; detection of ameloblastoma angiogenesis; and identification of ameloblastoma carcinogenesis.
Conclusions:
At present, some progress has been made in molecular biology and targeted therapy for ameloblastoma involving BRAF and SMO genes. The related non-coding RNAs, genes, proteins, and pathways involved in this review provide new ideas and directions for the occurrence and development of ameloblastoma and have the potential to become new gene therapy targets.
Insights
This review explores molecular biology and targeted therapies for ameloblastoma. Key findings highlight non-coding RNAs, genes, proteins, and pathways offering new diagnostic and therapeutic strategies for ameloblastoma.
Area of Science:
- Oral and Maxillofacial Pathology
- Oncology
- Molecular Biology
Background:
- Ameloblastoma is an odontogenic tumor with a high recurrence rate.
- Understanding its molecular underpinnings is crucial for effective treatment.
- Current therapeutic strategies often lack specificity.
Purpose of the Study:
- To systematically review molecular biology advancements in ameloblastoma.
- To discuss targeted therapeutic strategies based on molecular findings.
- To provide insights for improved diagnosis and treatment of ameloblastoma.
Main Methods:
- Comprehensive literature review of scientific articles on ameloblastoma.
- Inclusion of latest classification, epidemiology, molecular biology, and targeted therapy data.
- Analysis of identified non-coding RNAs, genes, proteins, and pathways.
Main Results:
- Identified 20 non-coding RNAs, 13 genes, 27 proteins, and 8 pathways implicated in ameloblastoma.
- These molecules influence ameloblastoma migration, differentiation, apoptosis, proliferation, angiogenesis, and carcinogenesis.
- BRAF and SMO genes show promise in targeted therapy.
Conclusions:
- Molecular biology research has advanced ameloblastoma understanding and targeted therapy.
- Identified molecular targets offer new avenues for ameloblastoma diagnosis and treatment.
- Non-coding RNAs, genes, proteins, and pathways represent potential novel gene therapy targets for ameloblastoma.
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